Ertapenem susceptibility of extended spectrum beta-lactamase-producing organisms
نویسندگان
چکیده
منابع مشابه
Extended-spectrum beta-lactamase-producing organisms.
Extended-spectrum beta-lactamases (ESBLs), which hydrolyse extended-spectrum cephalosporins and are inhibited by clavulanic acid, are spreading among Enterobacteriaceae. The CTX-M enzymes are replacing SHV and TEM enzymes as the prevalent type of ESBLs, principally in community-acquired infections caused by Escherichia coli. Associated infectious syndromes include mainly urinary tract infection...
متن کاملThe molecular epidemiology of extended-spectrum beta-lactamase producing organisms.
that hospital outbreaks of ESBL-producing E. coli may occur6. The reason why ESBL-producing K. pneumoniae is more likely to cause clusters of infection than E. coli has not been fully explored. While scores of scientists study bacterial pathogenesis, attention must surely be placed by the scientific community on the reasons why some strains are more “hospital-adapted” than others. Ability to at...
متن کاملEmergence of ertapenem resistance in an Escherichia coli clinical isolate producing extended-spectrum beta-lactamase AmpC.
Escherichia coli isolate MEV, responsible for a bloodstream infection, was resistant to penicillins, cephalosporins, and ertapenem. Molecular and biochemical characterization revealed the production of a novel, chromosome-borne, extended-spectrum AmpC (ESAC) β-lactamase with a Ser-282 duplication and increased carbapenemase activity. This study demonstrates for the first time that chromosome-bo...
متن کاملErtapenem for treatment of extended-spectrum beta-lactamase-producing and multidrug-resistant gram-negative bacteraemia.
INTRODUCTION Imipenem and meropenem are treatment of choice for extended-spectrum betalactamase (ESBL)-positive gram-negative bacteraemia. They may select for carbapenemresistant Acinetobacter baumannii and Pseudomonas aeruginosa; ertapenem may not do so as it is inactive against these bacteria. Clinical efficacy of ertapenem in ESBL-producing gramnegative bacteraemia is limited. MATERIALS AN...
متن کاملErtapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates.
Ertapenem resistance in Klebsiella pneumoniae is rare. We report on an ertapenem-nonsusceptible phenotype among 25 out of 663 (3.77%) extended-spectrum-beta-lactamase (ESBL)-producing K. pneumoniae isolates in a multicenter Israeli study. These isolates originated from six different hospitals and were multiclonal, belonging to 12 different genetic clones. Repeat testing using Etest and agar dil...
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ژورنال
عنوان ژورنال: Annals of Clinical Microbiology and Antimicrobials
سال: 2007
ISSN: 1476-0711
DOI: 10.1186/1476-0711-6-6